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Endothelial function and bradykinin in humans

B Hornig1, H Drexler

  • 1Abteilung Kardiologie, Medizinische Hochschule Hannover, Germany.

Drugs
|January 1, 1997
PubMed
Summary
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Bradykinin, a vasodilator, enhances endothelial function by releasing nitric oxide and other factors. Angiotensin converting enzyme (ACE) inhibitors increase bradykinin, improving blood vessel dilation and potentially benefiting cardiovascular conditions.

Area of Science:

  • Vascular Biology
  • Endocrinology
  • Pharmacology

Background:

  • The endothelium regulates vascular smooth muscle tone via secreted factors.
  • Endothelium-derived relaxing factors (EDRFs) are continuously released and their secretion increases with stimulation.
  • Bradykinin is a potent vasodilator implicated in regulating vascular tone.

Purpose of the Study:

  • To investigate the role of bradykinin in endothelium-mediated vasodilation.
  • To explore the impact of angiotensin converting enzyme (ACE) inhibitors on bradykinin levels and vascular function.
  • To determine if bradykinin mediates the beneficial vascular effects of ACE inhibitors.

Main Methods:

  • Studies involving humoral stimulation (acetylcholine, bradykinin) and physiological stimuli (blood flow, shear stress).

Related Experiment Videos

  • Assessment of endothelium-derived relaxing factors (EDRFs), including nitric oxide, prostacyclin, and endothelium-derived hyperpolarizing factor (EDHF).
  • Investigation of angiotensin converting enzyme (ACE) inhibitors and their effect on bradykinin levels and flow-dependent vasodilation.

    • Main Results:

    • Bradykinin stimulates the release of nitric oxide, prostacyclin, and EDHF, contributing to vasodilation.
    • ACE inhibitors increase bradykinin levels by inhibiting its degradation by kininase II.
    • ACE inhibition was shown to improve flow-dependent, endothelium-mediated vasodilation, an effect dependent on bradykinin.

    Conclusions:

    • Bradykinin plays a significant role in regulating vascular tone in human peripheral and coronary arteries.
    • The beneficial vascular effects of ACE inhibitors may be partly attributed to increased bradykinin availability and subsequent improvement in endothelial function.
    • These findings suggest a potential mechanism for the therapeutic benefits of ACE inhibitors in cardiovascular diseases like heart failure and coronary artery disease.