Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Implementation of quantitative perfusion imaging techniques for functional brain mapping using pulsed arterial spin

E C Wong1, R B Buxton, L R Frank

  • 1Department of Radiology, University of California, San Diego, La Jolla 92037-7756, USA. ecwong@ucsd.edu

NMR in Biomedicine
|June 1, 1997
PubMed
Summary

Quantitative perfusion imaging using pulsed arterial spin labeling (ASL) offers valuable insights. A new technique, QUIPSS II, improves accuracy by controlling tag bolus timing, enabling simultaneous perfusion and BOLD data collection for enhanced functional brain mapping.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Double pulsed field gradient diffusion MRI to assess skeletal muscle microstructure.

Magnetic resonance in medicine·2023
Same author

A randomised test of the effect of medical <i>v</i>. lay idiom on assessment of perceived mental health condition in the USA.

Epidemiology and psychiatric sciences·2020
Same author

Associations of Perceived Discrimination With Impaired Functioning in a Population Sample With Psychological Distress.

Psychiatry·2018
Same author

Post-stimulus fMRI and EEG responses: Evidence for a neuronal origin hypothesised to be inhibitory.

NeuroImage·2017
Same author

Assessing potential errors of MRI-based measurements of pulmonary blood flow using a detailed network flow model.

Journal of applied physiology (Bethesda, Md. : 1985)·2012
Same author

Rapid intravenous infusion of 20 mL/kg saline alters the distribution of perfusion in healthy supine humans.

Respiratory physiology & neurobiology·2012

Area of Science:

  • Neuroimaging
  • Physiology
  • Medical Physics

Background:

  • Functional MRI (fMRI) relies on BOLD contrast, but direct perfusion measurement offers complementary information.
  • Pulsed arterial spin labeling (ASL) is a non-invasive MRI technique for quantifying cerebral blood flow.
  • Existing ASL methods face challenges with transit delays and intravascular signal contamination.

Purpose of the Study:

  • To detail experimental considerations for quantitative perfusion imaging with pulsed ASL.
  • To introduce and evaluate a modified technique (QUIPSS II) for improved perfusion measurement accuracy.
  • To enable simultaneous acquisition of perfusion and BOLD data.

Main Methods:

  • Comparison of EPISTAR, PICORE, and FAIR tagging techniques for pulsed ASL.

Related Experiment Videos

  • Identification and analysis of systematic errors in perfusion quantification.
  • Development and implementation of the QUIPSS II technique with controlled tag bolus timing.
  • Design of pulse sequences for simultaneous perfusion and BOLD data acquisition.

    • Main Results:

    • EPISTAR, PICORE, and FAIR yielded similar perfusion results despite differing static tissue contrast.
    • Transit delay and intravascular signal were identified as major sources of systematic error.
    • QUIPSS II significantly reduced sensitivity to transit delay and intravascular signal.
    • Simultaneous perfusion and BOLD data acquisition was achieved with clean signal separation.
    • Multislice perfusion imaging complications related to static tissue signal were addressed by optimizing inversion pulse parameters.

    Conclusions:

    • QUIPSS II enhances the accuracy of quantitative perfusion imaging with pulsed ASL.
    • Simultaneous perfusion and BOLD imaging provide complementary information for functional brain mapping and BOLD mechanism studies.
    • Careful optimization of pulse sequence parameters is crucial for accurate multislice pulsed ASL.