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Subacute proximal diabetic neuropathy

I R Williams, R F Mayer

    Neurology
    |February 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Diabetic amyotrophy, a form of diabetic peripheral neuropathy, is a distinct clinical and pathologic entity. Disordered neuron-axonal metabolism may cause these nerve and muscle changes, leading to type 1 fiber predominance.

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    Area of Science:

    • Neurology
    • Metabolic Disorders
    • Pathology

    Background:

    • Diabetic peripheral neuropathy encompasses various clinical presentations.
    • Subacute proximal diabetic neuropathy, or diabetic amyotrophy, requires precise characterization.
    • Distinguishing diabetic amyotrophy from other neuropathies is crucial for accurate diagnosis and management.

    Observation:

    • Clinical, electrophysiologic, and histologic studies were conducted on three patients with diabetic amyotrophy.
    • Patients presented with a generalized neuropathy, not isolated nerve damage.
    • Muscle biopsies revealed histochemical changes, specifically type 1 fiber predominance.

    Findings:

    • Diabetic amyotrophy appears to be a distinct clinical and pathologic entity, separate from mononeuritis multiplex.

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  • The underlying pathology is postulated to involve disordered neuron-axonal metabolism.
  • Type 1 fiber predominance in muscle biopsies may result from adaptive changes in fiber metabolism due to altered usage.

    • Implications:

    • This study refines the understanding of diabetic amyotrophy as a specific neuropathy.
    • Identifying disordered metabolism as a key factor opens avenues for targeted research.
    • Understanding fiber type conversion offers insights into the pathophysiology of diabetic nerve damage.