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[Infectious endocarditis: prognostic factors of mortality in 131 cases]
M Oyonarte1, P Rojo, A Estévez
1Departamento de Medicina Interna, Hospital Clínico San Borja Arriarán, Santiago de Chile.
Revista Medica De Chile
|February 1, 1997
Summary
Antimicrobial treatment failure is the primary predictor of hospital mortality in infective endocarditis. This study compared survivors and deceased patients, finding key differences in complications and treatment outcomes.
Area of Science:
- Cardiology
- Infectious Diseases
- Internal Medicine
Background:
- Infective endocarditis (IE) carries a significant global hospital mortality rate, ranging from 13% to 40%.
- Understanding factors influencing mortality is crucial for improving patient outcomes in IE cases.
Purpose of the Study:
- To compare clinical, microbiological, echocardiographic factors, and complications between patients who died and those who survived infective endocarditis.
- Identify predictors of hospital mortality in infective endocarditis.
Main Methods:
- A cohort of 129 patients (14-74 years old) experiencing 131 episodes of infective endocarditis were followed during hospitalization.
- Clinical assessment, echocardiography, and microbiological studies were performed on all patients.
- Surgical interventions were indicated based on the presence of complications.
Main Results:
- Hospital mortality was 25.2% (33 of 131 episodes).
- Deceased patients showed higher frequencies of skin/mucosal septic manifestations, cardiac failure, and embolic episodes.
- Antimicrobial treatment failure occurred in 85% of deceased patients compared to 6% of survivors.
Conclusions:
- Antimicrobial treatment failure emerged as the most significant predictor of hospital mortality in this infective endocarditis cohort.
- Prompt and effective antimicrobial therapy is critical for improving survival rates in infective endocarditis.