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[Influence of cardiopulmonary bypass on lymphocyte function]
1First Department of Surgery, Yamaguchi University School of Medicine, Japan.
[Zasshi] [Journal]. Nihon Kyobu Geka Gakkai
|February 12, 1998
Summary
Cardiopulmonary bypass (CPB) impairs lymphocyte function. Prolonged CPB may contribute to delayed recovery of lymphocyte function and elevated IL-6 and IL-8 levels post-surgery.
Area of Science:
- Immunology
- Cardiovascular Surgery
- Critical Care Medicine
Context:
- Lymphocyte function impairment is a known complication following cardiopulmonary bypass (CPB).
- Understanding the factors influencing lymphocyte recovery post-CPB is crucial for patient outcomes.
Purpose:
- To investigate the correlation between prolonged lymphocyte function impairment after CPB and specific clinical and immunological parameters.
- To compare surgical parameters, white blood cell counts, lymphocyte subsets, and serum cytokine levels between patients with normal and delayed lymphocyte recovery.
Summary:
- This study assessed lymphocyte stimulation tests (LST) in 28 adult patients before and after CPB.
- All patients exhibited impaired LST post-CPB, with some showing delayed recovery (delayed group, n=12) compared to others (normal group, n=16).
- The delayed group showed significantly higher serum IL-6 and IL-8 levels and a slower recovery of OKT4-positive cells post-surgery.
Impact:
- Prolonged CPB duration may be a contributing factor to the extended impairment of lymphocyte function observed in some patients.
- Findings suggest a link between elevated inflammatory cytokines (IL-6, IL-8) and delayed immune recovery post-CPB.
- This research aids in identifying patients at risk for prolonged immune dysfunction after cardiac surgery involving CPB.