Related Experiment Videos
A polymorphism in the gene for the angiotensin II type 1 receptor is not associated with hypertension
S Schmidt1, J Beige, M Walla-Friedel
1Department of Internal Medicine, University of Heidelberg, Germany.
Background:
A mutation in the gene for the angiotensin II type 1 (AT1) receptor (A1166C) has been reported to be associated with primary hypertension.
Objective:
To determine whether this observation could be confirmed with a different population sample.
Design:
We examined 414 individuals with primary hypertension and 172 normotensive controls.
Methods:
The mutation in the gene for the AT1 receptor was detected using restriction polymerase chain reaction.
Conclusions:
We detected no association of the AT1 receptor polymorphism with hypertension, but a trend towards a decreased prevalence of the 1166C allele among hypertensive patients with a late age at diagnosis (> or = 50 years) was observed.