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[Prolactin as an immunomodulator]

A Leaños Miranda1, M G Quintal Alvarez, H Cervera Castillo

  • 1Laboratorio de Autoinmunidad, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, IMSS.

Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|February 12, 1998
PubMed
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Prolactin, a pituitary hormone, modulates immune responses by influencing lymphocyte proliferation. Altered prolactin levels are linked to autoimmune diseases, suggesting its potential as an immunomodulator.

Area of Science:

  • Endocrinology
  • Immunology
  • Molecular Biology

Context:

  • Prolactin is a pituitary hormone with known immune system interactions.
  • Immune cells, specifically lymphocytes, possess prolactin receptors and can produce prolactin.
  • Serum prolactin levels are altered in various autoimmune conditions.

Purpose:

  • To review the multifaceted role of prolactin in immune responses.
  • To explore prolactin's function as a potential immunomodulator.
  • To discuss the clinical relevance of prolactin's immunomodulatory effects.

Summary:

  • Prolactin influences lymphocyte proliferation and immune activity.
  • Both low and high prolactin levels elicit distinct immune responses in vitro.
  • Elevated prolactin is observed in autoimmune diseases such as systemic lupus erythematosus and Reiter syndrome.

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Impact:

  • Highlights prolactin's significant role in immune system regulation.
  • Suggests prolactin as a potential therapeutic target for autoimmune diseases.
  • Underscores the need for further research into the clinical applications of prolactin modulation.