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The biochemical effect of auromomycin on bacterial cells
The Journal of Antibiotics
|July 1, 1979
Abstract:
The mechanism of action of auromomycin was studied with intact cells of Bacillus subtilis. The antibiotic exhibited a preferential inhibition of DNA synthesis over RNA and protein syntheses. The strand scission of cellular DNA was induced by the drug, and DNA was degraded into acid-soluble fragments. The results suggested that DNA is the chemoreceptor of auromomycin.