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The cyclin box fold: protein recognition in cell-cycle and transcription control
M E Noble1, J A Endicott, N R Brown
1Oxford Centre for Molecular Sciences, UK.
Trends in Biochemical Sciences
|January 20, 1998
Abstract:
Regulation of both the cell cycle and gene transcription is essential for orderly progression of cell growth and division. Recent results on the structures of two cyclins, cyclin A and cyclin H, and two transcription factor mediator proteins, TFIIB and the A pocket region of the retinoblastoma tumour suppressor protein (Rb), show that they share domains with a strikingly similar alpha-helical topology, despite remote sequence identity.