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Treatment with rhG-CSF for osteomyelitis in a patient with p47-phox-deficient chronic granulomatous disease
H Isotani1, Y Fukumoto, H Kawamura
1Department of Internal Medicine, Hirakata City Hospital, Osaka, Japan.
Abstract:
A 24-year-old woman with osteomyelitis was diagnosed as having p47-phox-deficient chronic granulomatous disease (CGD). The patient showed a marked deficiency of p47-phox, which is very rare in Japan. As the clinical response to various antibiotics including sulfamethoxazole-trimethoprim was not satisfactory, we added recombinant human granulocyte colony-stimulating factor (rhG-CSF) to the treatment protocol. We report the beneficial clinical course of the patient, together with the effect of rhG-CSF on the granulocyte function, and the present report indicates that rhG-CSF is useful for the treatment of antibiotic-resistant infection in the variant type of p47-phox-defective CGD.