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GENEHUNTER: application to analysis of bipolar pedigrees and some extensions
1Section of Biostatistics, Mayo Clinic/Mayo Foundation, Rochester, Minnesota, USA.
Genetic Epidemiology
|January 1, 1997
Abstract:
A newly developed nonparametric multipoint linkage analysis (NPL) by Kruglyak et al. [1996] was applied to the data set from the Johns Hopkins Bipolar Study available through the GAW10 workshop. Our results from GENEHUNTER do not support the analyses of Stine et al. [1995]. Some possible extensions to incorporate unaffecteds are also discussed.