Caution in the interpretation of MLS
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Updated: Oct 23, 2026

Detection of Architectural Distortion in Prior Mammograms via Analysis of Oriented Patterns
Published on: August 30, 2013
S Eichenbaum-Voline1, E Génin, M C Babron
1Laboratory of Medical Statistics, URA CNRS 1323, University of Paris V, France.
Abstract:
We study the statistical properties of the maximum likelihood score (MLS) test. We show that the criteria for reaching conclusions about linkage are not the same for single point analysis as for multipoint, where the maximization is performed over an additional parameter, the position in the marker interval where the MLS is computed. In addition, this test is shown to be very sensitive to errors in allele frequencies and recombination fraction.
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