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Opposing actions of BMP3 and TGF beta 1 in human bone marrow stromal cell growth and differentiation
C Faucheux1, F Ulysse, R Bareille
1INSERM U. 443, Université Victor Segalen Bordeaux, France.
Biochemical and Biophysical Research Communications
|January 22, 1998
Abstract:
BMP3 and TGF beta 1 were found to induce opposite effects on human bone marrow stromal cells both in cell proliferation and cell differentiation and on calcium deposition onto the extracellular matrix. Moreover, BMP3 may exert, in part, the inhibitory effect of TGF beta 1 through decreasing the affinity of TGF-beta for its receptors which are now identified in these human bone cells.