Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oxygen solubilization by lung surfactant

W F Stanaszek, B Ecanow, R S Levinson

    Journal of Pharmaceutical Sciences
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Relative bioavailability of danazol in dogs from liquid-filled hard gelatin capsules.

    International journal of pharmaceutics·1999
    Same author

    Adenovirus E1A specifically blocks SWI/SNF-dependent transcriptional activation.

    Molecular and cellular biology·1996
    Same author

    Essential role of Swp73p in the function of yeast Swi/Snf complex.

    Genes & development·1996
    Same author

    Complete sequence of the genomic RNA of O'nyong-nyong virus and its use in the construction of alphavirus phylogenetic trees.

    Virology·1990
    Same author

    Hemoglobin in a coacervate system.

    Biomaterials, artificial cells, and artificial organs·1990
    Same author

    Dealing with DRGs: analysis of serum theophylline assays in Medicare patients.

    Hospital pharmacy·1985
    Same journal

    Green, renewable, or low-carbon? A framework for informed solvent selection in pharmaceutical sciences.

    Journal of pharmaceutical sciences·2026
    Same journal

    Theranostic potential of ramucirumab functionalized magnetoliposomes for targeted delivery of sorafenib and MRI.

    Journal of pharmaceutical sciences·2026
    Same journal

    Intranasal mucoadhesive chitosan microspheres of ranolazine: Formulation, design, and pharmacokinetic evaluation.

    Journal of pharmaceutical sciences·2026
    Same journal

    Evolving landscape of drug development for pediatric rare diseases-from successes to strategies for addressing unmet needs.

    Journal of pharmaceutical sciences·2026
    Same journal

    A mathematical framework for predicting tablet weight variability from blend particle size distribution and tooling geometry.

    Journal of pharmaceutical sciences·2026
    Same journal

    Recrystallization can stop nitrosamine formation in ranitidine hydrochloride.

    Journal of pharmaceutical sciences·2026
    See all related articles

    Lung surfactants enhance oxygen transport by solubilizing gas within micelles. Higher surfactant concentrations, especially above the critical micelle concentration (CMC), significantly increase oxygen absorption, suggesting a partitioning mechanism.

    Area of Science:

    • Biochemistry
    • Physiology
    • Materials Science

    Background:

    • Biological gas transport mechanisms are crucial for physiological function.
    • Lung surfactants play a vital role in respiratory system dynamics.
    • Understanding gas solubilization can elucidate novel transport pathways.

    Purpose of the Study:

    • To investigate the role of lung surfactants in oxygen gas solubilization.
    • To determine the relationship between surfactant concentration and oxygen absorption.
    • To explore the potential of micelle formation in gas transport.

    Main Methods:

    • Utilizing dog lung surfactants at varying concentrations.
    • Employing a modified tonometer as an absorption chamber for gas analysis.
    • Quantifying gas solubilization using Gas Chromatography (GC).

    Related Experiment Videos

    Main Results:

    • Surfactant concentration was identified as a critical factor in gas solubilization.
    • Oxygen absorption increased significantly at surfactant concentrations above the critical micelle concentration (CMC).
    • Anomalously high gas absorption was observed above the CMC.

    Conclusions:

    • Lung surfactants can solubilize oxygen, suggesting a role in biological gas transport.
    • Micelle formation within surfactants is a likely mechanism for enhanced gas partitioning.
    • This partitioning effect offers a potential explanation for observed gas absorption levels.