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Plasma cholesteryl ester transfer protein activity in hyper- and hypothyroidism
The Journal of Clinical Endocrinology and Metabolism
|January 22, 1998
Summary
Thyroid dysfunction significantly alters cholesteryl ester transfer protein (CETP) activity, increasing it in hyperthyroidism and decreasing it in hypothyroidism. Treatment normalizes CETP activity, indicating a direct link between thyroid status and lipoprotein metabolism.
Area of Science:
- Endocrinology
- Lipid Metabolism
- Cardiovascular Research
Background:
- Thyroid dysfunction impacts lipoprotein metabolism.
- Cholesteryl ester transfer protein (CETP) plays a key role in lipoprotein metabolism and reverse cholesterol transport.
- Understanding CETP activity in thyroid disorders is crucial for cardiovascular risk assessment.
Purpose of the Study:
- To investigate the effect of thyroid dysfunction on plasma cholesteryl ester transfer protein (CETP) activity.
- To determine if CETP activity changes are reversible with thyroid hormone level normalization.
Main Methods:
- Assayed plasma CETP activity in hyperthyroid and hypothyroid patients before and after treatment.
- Measured cholesteryl ester transfer from radiolabeled HDL to apoB-containing lipoproteins.
- Correlated CETP activity with free thyroxine (free T4) levels.
Main Results:
- Plasma CETP activity was significantly increased in hyperthyroid patients compared to controls.
- Plasma CETP activity was significantly decreased in hypothyroid patients compared to controls.
- CETP activity normalized after treatment in both hyperthyroid and hypothyroid patients, with a strong positive correlation observed between log(free T4) and CETP activity.
Conclusions:
- Both hyperthyroidism and hypothyroidism are associated with significant alterations in plasma CETP activity.
- These alterations in CETP activity are corrected upon achieving euthyroid status.
- Thyroid hormone levels directly influence CETP activity and lipoprotein metabolism.