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Updated: Aug 11, 2026
04:47
A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies
Published on: February 23, 2018
Increased potency of Fc-receptor-targeted antigens
P M Guyre1, R F Graziano, J Goldstein
1Department of Physiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA. paul.guyre@dartmouth.edu
Cancer Immunology, Immunotherapy : CII
|January 22, 1998
Summary
Targeting antigens to the Fc gamma RI (CD64) receptor on antigen-presenting cells enhances immune responses. This approach improves vaccine effectiveness by increasing antigen uptake and T cell activation for better immunity.
Area of Science:
- Immunology
- Vaccinology
- Molecular Biology
Background:
- Efficient antigen uptake and processing by antigen-presenting cells (APCs) are crucial for T cell-mediated immunity and vaccine efficacy.
- Fc gamma RI (CD64), expressed on professional APCs like monocytes and dendritic cells, mediates antigen uptake and T cell activation.
Purpose of the Study:
- To review literature supporting the in vivo efficacy of CD64-targeted antigens.
- To demonstrate enhanced immunogenicity of a fusion protein targeting CD64.
Main Methods:
- Literature review on CD64-mediated antigen presentation.
- Development and testing of a fusion protein combining HIV gp120 and an anti-CD64 antibody (H22) in CD64 transgenic mice.
Main Results:
- Previous studies showed enhanced peptide presentation via CD64 targeting.
- The fusion protein demonstrated enhanced immunogenicity in CD64 transgenic mice, indicating successful antigen targeting.
Conclusions:
- Targeting antigens to CD64 is a promising strategy to improve vaccine effectiveness.
- This approach enhances antigen presentation and T cell activation in vivo.
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