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Assessing cognition in Alzheimer disease research
1Silberstein Aging and Dementia Research Center, New York University Medical Center, NY 10016, USA.
Alzheimer Disease and Associated Disorders
|January 1, 1997
Summary
Cognitive assessments are crucial for Alzheimer disease research, measuring cognitive decline and evaluating treatment efficacy. This review examines suitable cognitive tests and their application in Alzheimer
Area of Science:
- Neuroscience
- Neurology
- Psychometrics
Background:
- Cognitive impairment is the hallmark of Alzheimer disease (AD).
- Cognitive assessments are vital outcome measures in AD research.
- Evaluating cognitive function is essential for understanding disease progression and treatment effectiveness.
Purpose of the Study:
- To review cognitive functions affected in Alzheimer disease.
- To outline criteria for appropriate cognitive performance tests.
- To analyze major cognitive batteries used in AD research and discuss future directions.
Main Methods:
- Literature review of cognitive functions in Alzheimer disease.
- Analysis of characteristics, strengths, and weaknesses of cognitive assessment tools.
- Summary of contributions from the Alzheimer's Disease Cooperative Study.
Main Results:
- Cognitive decline is central to Alzheimer disease.
- Specific cognitive functions are targeted by validated assessment tools.
- Various cognitive batteries exist, each with unique properties for outcome measurement.
Conclusions:
- Appropriate cognitive tests are indispensable for Alzheimer disease research.
- Continued development of sensitive and specific cognitive measures is critical.
- Future research should focus on refining existing and developing novel cognitive assessments for AD.