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Predictive factors for multiple pregnancy in in vitro fertilization
S Bassil1, C Wyns, D Toussaint-Demylle
1Department of Gynecology, University Hospital St. Luc, Catholic University of Louvain, Brussels, Belgium. bassil@gyne.ucl.be
The Journal of Reproductive Medicine
|January 23, 1998
Summary
For in vitro fertilization (IVF), replacing two good-quality embryos maximizes successful pregnancy outcomes. This strategy is recommended for patients with a good prognosis, irrespective of age or prior IVF attempts, to reduce multiple pregnancies.
Area of Science:
- Reproductive Medicine
- In Vitro Fertilization (IVF)
Background:
- Multiple pregnancies resulting from IVF increase risks for both mother and child.
- Identifying factors that predict multiple pregnancy rates is crucial for optimizing IVF outcomes.
Purpose of the Study:
- To investigate predictive factors associated with multiple pregnancy rates in in vitro fertilization (IVF).
Main Methods:
- Retrospective analysis of 1,736 in vitro fertilization (IVF) cycles.
- Statistical correlation analysis incorporating embryo quality, quantity, maternal age, and stimulation parameters.
Main Results:
- A total of 453 pregnancies were achieved, with singleton, twin, and triplet rates at 44%, 22%, and 4.5% respectively.
- Positive correlations were observed between the number and quality of transferred embryos and multiple pregnancy occurrence.
- Maternal age, stimulation parameters, and embryo characteristics also showed significant correlations with pregnancy outcomes, varying for singleton, twin, and triplet gestations.
Conclusions:
- For patients with a favorable IVF prognosis, transferring a maximum of two high-quality embryos is recommended.
- This approach aims to reduce the incidence of multiple pregnancies while maximizing the chance of a successful singleton birth.
- Maternal age and previous IVF attempt history should not influence the decision to transfer more than two embryos in good-prognosis cases.