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11 beta-substituted 13 beta-ethyl gonane derivatives exhibit reversal of antiprogestational activity
P N Rao1, J W Cessac, R P Blye
1Department of Organic Chemistry, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245-0549, USA.
Steroids
|January 23, 1998
Abstract:
The syntheses of three 17 alpha-acetoxy-13 beta-ethyl-11 beta-aryl-18,19-dinorpregna-4,9-diene-3,20 diones from levonorgestrel are described. Despite their close structural similarity to the antiprogesterone CDB-2914, one of the compounds exhibits agonistic progestational activity, and the other two compounds are totally inactive.