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Delayed adverse reactions to nonionic monomeric contrast-enhanced media
1Department of Radiology, Showa University School of Medicine, Tokyo, Japan.
Investigative Radiology
|January 23, 1998
Summary
Delayed adverse reactions to nonionic contrast media occurred in 2.1% of patients. The most common reactions were mild skin reactions like itching and urticaria, appearing within 24 hours.
Area of Science:
- Radiology and Imaging
- Pharmacovigilance
Background:
- Delayed adverse reactions to contrast media are not well-established.
- Nonionic contrast media are widely used in computed tomography (CT).
Purpose of the Study:
- To determine the frequency and symptoms of delayed adverse reactions.
- To investigate reactions specifically to nonionic monomeric contrast media.
Main Methods:
- Retrospective analysis of patients undergoing CT scans.
- Comparison of delayed adverse reactions between enhanced and unenhanced CT groups.
Main Results:
- Delayed adverse reactions occurred in 12.4% of enhanced CT patients and 10.3% of unenhanced CT patients.
- The specific frequency of delayed adverse reactions to nonionic contrast media was 2.1%.
- Mild skin reactions, including itching and urticaria within 24 hours, were most common.
Conclusions:
- The frequency of delayed adverse reactions to nonionic monomeric contrast media is 2.1%.
- Itching and limited urticaria are the predominant delayed adverse reactions.