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Serum androgen levels in hyperthyroid women

H Ueshiba1, S Takeda, H Matoba

  • 1First Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan.

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [And] German Diabetes Association
|January 1, 1997
PubMed
Summary

Hyperthyroidism elevates specific androgen metabolites like dihydrotestosterone (DHT) and 5 alpha-reductase activity. Treatment normalized these androgen levels within three months, though sex hormone-binding globulin (SHBG) recovery lagged.

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Area of Science:

  • Endocrinology
  • Metabolism
  • Reproductive Health

Background:

  • Thyroid hormones significantly influence androgen metabolism.
  • Limited research exists on simultaneous androgen metabolism alterations in clinical thyroid disorders.

Purpose of the Study:

  • To investigate changes in thyroid hormones and androgens during hyperthyroidism treatment.
  • To assess the impact of hyperthyroidism on androgen metabolism markers.

Main Methods:

  • Studied 15 female patients with Graves' disease hyperthyroidism.
  • Measured serum concentrations of free T4, free T3, testosterone, androstenedione, dihydrotestosterone, 3 alpha-diol, androsterone, and SHBG via radioimmunoassays.
  • Included 10 healthy women as normal controls.

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Main Results:

  • Pre-treatment: Elevated dihydrotestosterone, 3 alpha-diol, androsterone, SHBG, and DHT/T ratio (indicating increased 5 alpha-reductase activity) in hyperthyroid patients compared to controls.
  • Post-treatment: Thyroid function normalized within 2 months; androgen levels and DHT/T ratio normalized within 3 months.
  • SHBG levels decreased gradually but remained elevated at 6 months, showing a recovery lag compared to androgen levels.

Conclusions:

  • Hyperthyroidism is associated with altered androgen metabolism, specifically increased 5 alpha-reductase activity and elevated androgen metabolites.
  • Treatment of hyperthyroidism effectively normalizes these androgen alterations.
  • Sex hormone-binding globulin exhibits a delayed normalization pattern post-treatment.