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The soft keratoprosthesis

D R Caldwell1

  • 1Tulane University Medical Center, School of Medicine, Department of Ophthalmology, New Orleans, USA.

Transactions of the American Ophthalmological Society
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

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This study developed an improved keratoprosthesis with a biocolonizable skirt and soft optic for global use. The new design enhances tissue integration and patient outcomes, offering a better alternative to rigid optics.

Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Surgical Innovation

Background:

  • Developing advanced keratoprosthesis designs is crucial for treating corneal blindness worldwide.
  • Previous rigid optic keratoprosthesis models faced challenges with extrusion and tissue interface complications.

Observation:

  • A 20-year study involved in vivo animal implantation and clinical trials to assess biocompatibility and durability.
  • Porous, biocolonizable haptics embedded in the sclera were key to the new surgical technique.

Findings:

  • An optimal design featured 6 equidistantly placed haptics and a soft, elastomeric optic made of aliphatic polyether-based urethane.
  • Polytetrafluoroethylene (PTFE) with 60 μm pores was selected for the ingrowth material, bonded via injection molding.
  • Sclerally embedded haptics demonstrated excellent tissue integration, preventing extrusion.

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Implications:

  • The new keratoprosthesis offers improved scleral anchoring, better management of shearing forces, and reduced intraocular irritation.
  • Enhanced visual field, funduscopic view, and cosmetic appearance represent significant advancements over prior models.
  • This design has the potential to improve patient quality of life and surgical visualization globally.