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[Systemic rheumatoid arthritis]

V Lilleby1, J T Gran

  • 1Oslo Sanitetsforenings, Revmatismesykehus Rikshospitalet.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|January 24, 1998
PubMed
Summary
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Systemic rheumatoid disease, characterized by vasculitis or serositis in rheumatoid arthritis patients, affects males more frequently. Treatment with cyclophosphamide and corticosteroids shows effectiveness.

Area of Science:

  • Rheumatology
  • Immunology
  • Internal Medicine

Background:

  • Systemic rheumatoid disease involves rheumatoid arthritis with vasculitis or serositis.
  • It affects males more than females and can impact multiple organs.

Observation:

  • Clinical or histological evidence of vasculitis/serositis defines systemic rheumatoid disease.
  • Patients often present with rheumatoid nodules, joint deformities, and erosions, even with inactive arthritis.
  • High titers of immunoglobulin G rheumatoid factor are associated with this condition.

Findings:

  • Vasculitis can manifest in nearly any organ.
  • An intermittent bolus regimen of cyclophosphamide and corticosteroids appears effective for managing systemic rheumatoid disease.

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Implications:

  • Understanding systemic rheumatoid disease is crucial for comprehensive rheumatoid arthritis patient care.
  • Effective treatment strategies, like cyclophosphamide and corticosteroid therapy, offer hope for managing this severe manifestation.