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Related Experiment Videos

The mouse atlas and graphical gene-expression database

Davidson1, Bard, Brune

  • 1MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK

Seminars in Cell & Developmental Biology
|January 27, 1998
PubMed
Summary

Storing extensive mouse gene-expression data requires a graphical database. This project maps gene data onto 3-D mouse embryo models for efficient storage and retrieval.

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Area of Science:

  • Developmental Biology
  • Bioinformatics
  • Computational Biology

Background:

  • Gene-expression data from mouse development is rapidly accumulating.
  • Existing storage formats are inadequate for this large, graphical data.
  • Early developmental stages present challenges in mapping data to anatomical tissues.

Purpose of the Study:

  • To develop a database system for handling graphical gene-expression data.
  • To integrate gene expression profiles with 3-D reconstructions of mouse embryos.
  • To create a system for efficient data submission and querying.

Main Methods:

  • Mapping gene-expression data onto delineated 3-D reconstructions of mouse embryos.
  • Developing CD-ROMs for local storage of 3-D reconstructions.

Related Experiment Videos

  • Establishing a central gene-expression database at a host site.
  • Implementing a Java-based interface for internet-based data exchange.

    • Main Results:

    • A database system capable of storing graphical gene-expression data has been constructed.
    • The system links local 3-D embryo reconstructions with a central database.
    • A functional Java interface facilitates data submission and querying.

    Conclusions:

    • The developed database system effectively manages large-scale graphical gene-expression data.
    • This approach enables integrated analysis of gene expression and embryonic morphology.
    • The system provides a robust platform for future mouse developmental studies.