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A close association between brain lacuna infarction and renal surface irregularity
1Department of Clinical Research, Tohsei National Hospital, Japan.
American Journal of Hypertension
|January 27, 1998
Summary
Brain lacunae, identified via MRI, show a significant association with the severity of renal ischemia, assessed by CT. This suggests renal ischemia may play a role in the development of brain lacunae.
Area of Science:
- Neurology
- Nephrology
- Radiology
Background:
- Brain lacunae are small lesions visible on MRI.
- Renal ischemia, often due to arteriosclerosis, affects kidney function.
- The relationship between these conditions requires further investigation.
Purpose of the Study:
- To investigate the association between brain lacunae and renal ischemia severity.
- To determine if renal ischemia is a potential cause of brain lacunae.
Main Methods:
- Retrospective review of 114 cases with both brain MRI and kidney CT scans.
- Brain lacunae defined as T1-weighted low intensity areas (5-10 mm).
- Renal surface irregularity graded as absent, mild, or severe.
Main Results:
- Prevalence of brain lacunae was 13.3% (absent irregularity), 31.1% (mild), and 70.8% (severe).
- A highly significant relationship (P < .001) was found between brain lacunae and renal surface irregularity severity.
- The association remained significant in hypertensive patients over 60.
Conclusions:
- Brain lacunae are closely associated with the severity of renal ischemia.
- Renal ischemia is implicated as a potential causative factor for brain lacunae.