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AgNOR expression in CNS neoplasms

N Husain1, M Bagchi, M Husain

  • 1Department of Pathology and Neurosurgery, K.G. Medical College, Lucknow.

Indian Journal of Pathology & Microbiology
|January 28, 1998
PubMed
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Silver colloid staining of nucleolar organiser regions (AgNORs) effectively differentiates normal, benign, and malignant central nervous system (CNS) tissues. This simple technique serves as a valuable proliferative marker for tumor assessment.

Area of Science:

  • Neuropathology
  • Oncology
  • Molecular Biology

Background:

  • Silver colloid staining of nucleolar organiser regions (AgNORs) is a recognized method for evaluating tumor proliferative potential.
  • Assessing proliferative indices is crucial for diagnosing and classifying central nervous system (CNS) neoplasms.

Purpose of the Study:

  • To evaluate AgNOR indices in normal, reactive CNS tissue, and both benign and malignant CNS neoplasms.
  • To establish cut-off values for differentiating neoplastic from non-neoplastic tissues and benign from malignant tumors.
  • To assess the utility of AgNOR indices in distinguishing between low-grade and high-grade astrocytomas.

Main Methods:

  • Analysis of AgNOR indices in 122 CNS tissue samples (22 controls, 100 neoplasms).
  • Statistical comparison of AgNOR indices across different tissue types and tumor grades.

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  • Utilisation of Receiver Operating Characteristic (ROC) curves to determine diagnostic cut-off values.

    • Main Results:

    • Mean AgNOR indices were 0.95 for controls, 1.25 for benign neoplasms, and 2.12 for malignant neoplasms.
    • Statistically significant differences in AgNOR indices were observed between controls and cases (p < 0.001), and between benign and malignant tumors (p = 0.002).
    • Significant differences were also found between low and high-grade astrocytomas (p < 0.001).
    • ROC curve analysis yielded cut-off values: 1.10 for neoplastic vs. non-neoplastic, 1.75 for benign vs. malignant, and 1.62 for low-grade vs. anaplastic astrocytomas.

    Conclusions:

    • AgNOR indices show a progressive increase from normal to reactive, benign, and malignant CNS tissues.
    • AgNOR staining is a useful and simple proliferative marker for CNS tumor assessment.
    • The established cut-off values aid in the differential diagnosis of CNS lesions.