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Related Experiment Videos

Para Bombay phenotype--a case report

J Mathai1, P V Sulochana, S Sathyabhama

  • 1Division of Blood Transfusion Services, Sree Chitra Thirunal Institute for Medical Sciences and Technology, Trivandrum.

Indian Journal of Pathology & Microbiology
|January 28, 1998
PubMed
Summary
This summary is machine-generated.

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The rare para Bombay phenotype, unlike the classic Bombay type, showed suppressed red blood cell antigens but normal blood group substances in saliva. This case underscores the importance of both forward and reverse blood group testing for accurate ABO blood grouping.

Area of Science:

  • Immunogenetics
  • Hematology
  • Blood Group Serology

Background:

  • The Bombay phenotype (Oh) is a rare blood group characterized by the absence of A, B, and H antigens on red blood cells and the presence of anti-A, anti-B, and anti-H in serum.
  • Genetic factors, including modifying genes, are postulated to influence the expression of ABO genes, leading to variations like the Bombay phenotype.
  • Accurate blood group determination is crucial for safe blood transfusions and understanding human genetic diversity.

Observation:

  • A case presenting with a discrepancy between red blood cell agglutination and serum reactions (forward and reverse grouping) was identified.
  • This individual exhibited characteristics of a para Bombay phenotype, a variant of the classical Bombay type.
  • Unlike the classic Bombay phenotype, red blood cells showed partial antigen suppression, and saliva contained normal amounts of blood group substances.

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Findings:

  • The para Bombay phenotype case demonstrated that ABO antigens could be detected using elution tests, indicating partial suppression rather than complete absence.
  • The presence of appropriate blood group substances in saliva distinguished this case from the classical Bombay phenotype.
  • Discrepancies in forward and reverse blood group grouping were key to identifying this rare phenotype.

Implications:

  • This case highlights the heterogeneity within the Bombay blood group system and the importance of recognizing variants.
  • The findings emphasize the necessity of performing both forward (cell grouping) and reverse (serum grouping) tests in ABO blood grouping to detect discrepancies.
  • Comprehensive blood group analysis, including antigen detection and secretor status, is vital for clinical practice and transfusion compatibility.