[Autoimmune cell reaction following the administration of an allergen from Ambrosia pollen]

Data are presented pointing to the principal possibility of using micromodification of the local hemolysis test (suggested by Klemparskaya) for the purpose of characteristics of pollen allergens. In administration to male mice, weighing 18 to 20 g of 0.25 ml of the allergen prepared from a 3% suspension of ambrosia pollen in water-salt Evans-Cock fluid there was a sharp rise in the spleen of cells synthesizing antibodies against own erythrocytes of these animals on the 4th-6th day after the immunization. The water-salt solution included into the composition of the allergen promoted to some extent stimulation of these processes. The allergen possessed a high allergenic activity in the skin test on man and contained 0.3 ml of protein nitrogen per 1 ml. A possibility of autoimmune influence of these preparations in hyposensitizing therapy of man is supposed.