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Updated: Aug 14, 2026

Nuclear Magnetic Resonance Spectroscopy for the Identification of Multiple Phosphorylations of Intrinsically Disordered Proteins
Published on: December 27, 2016
[Proteins of the nuclear matrix and their phosphorylation in normal and tumor cells]
Abstract:
The protein composition of the nuclear matrix of normal and tumor cells is discussed. A characteristic feature of the latter is the predominance of high molecular weight polypeptides containing mainly glyco- and phosphoproteins. Only few of them are identified. Nuclear matrix preparations from tumors differ by the presence of fibronectin and phosphotyrosine-containing proteins with a molecular mass of nearly 180 and 170 kDa as well as of high turnover of high molecular weight protein group and inhibition of their biosynthesis by chloramphenicol.
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