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Development and validation of a method to extract and quantitate paromomycin and gentamicin from an Aquaphilic cream

J Pick1, L L Olson, W Y Ellis

  • 1SRI International, Life Sciences Division, Menlo Park, CA 94025, USA.

Journal of Pharmaceutical and Biomedical Analysis
|February 3, 1998
PubMed

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Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...