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A microflow amperometric glucose biosensor

B C Towe1, V B Pizziconi

  • 1Department of Chemical and Bio, Materials Engineering, Arizona State University, Tempe 85287, USA. icbct@asuvm.inre.asu.edu

Biosensors & Bioelectronics
|January 1, 1997
PubMed
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This study introduces a novel glucose sensor ideal for continuous monitoring. It shows reduced sensitivity to oxygen and enzyme changes, offering a promising alternative for blood glucose measurement.

Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry

Background:

  • Conventional polarographic glucose sensors face challenges with oxygen sensitivity and variable enzyme activity.
  • Microdialysis-based glucose sensors offer potential for continuous subcutaneous or intravascular monitoring.

Purpose of the Study:

  • To evaluate a novel flow-through enzyme bed glucose sensor for microdialysis applications.
  • To assess the sensor's performance in a canine model with a near-surface blood vessel.
  • To investigate the impact of protein deposition on sensor function.

Main Methods:

  • Utilized a flow-through enzyme bed and reaction endpoint approach for glucose sensing.
  • Employed microdialysis fiber placement in a canine model for blood glucose sampling.
  • Analyzed protein deposition effects on intravascular membrane fiber transport.

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Main Results:

  • The novel sensor configuration demonstrated relative insensitivity to blood oxygen fluctuations.
  • Compared to polarographic sensors, it showed better stability against factors affecting enzyme activity.
  • Observed a progressive decline in intravascular membrane fiber transport due to protein deposition.

Conclusions:

  • The developed glucose sensor is well-suited for microdialysis-type subcutaneous or intravascular applications.
  • Protein deposition presents a challenge that requires consideration in the design of intravascular glucose sensors.
  • This sensor design offers advantages over conventional methods for continuous glucose monitoring.