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Related Experiment Videos

Application of fuzzy logic in multicomponent analysis by optodes

M Wollenweber1, J Polster, T Becker

  • 1Lehrstuhl für Allgemeine Chemie und Biochemie, Technical University of Munich, Freising-Weihenstephan, Germany.

Biosensors & Bioelectronics
|January 1, 1997
PubMed
Summary

Fuzzy logic successfully determined ampicillin and penicillin concentrations simultaneously using optode arrays and UV-VIS spectroscopy. This method offers a reliable approach for analyzing complex mixtures in chemical sensing.

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Preface.

Isotopes in environmental and health studies·2011

Area of Science:

  • Analytical Chemistry
  • Chemical Sensing
  • Spectroscopy

Background:

  • Optode arrays combined with flow injection analysis (FIA) and UV-VIS spectroscopy are effective for substrate concentration determination.
  • Kinetics and fuzzy logic can enhance the analysis of complex chemical mixtures.

Purpose of the Study:

  • To simultaneously determine ampicillin and penicillin concentrations in artificial mixtures.
  • To evaluate the application of fuzzy logic for quantitative analysis using optode array data.

Main Methods:

  • Utilized transient diffuse reflectance spectra from four optodes in the visible wavelength region.
  • Employed flow injection analysis, UV-VIS spectroscopy, and kinetic analysis.
  • Applied fuzzy logic modeling after data pre-processing to reduce spectral information.

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Main Results:

  • Successfully discriminated between samples by adjusting receptor gel composition and working pH.
  • Developed a fuzzy model capable of simultaneous determination of ampicillin and penicillin.
  • Validated the fuzzy model using an independent test data set.

Conclusions:

  • Fuzzy logic is a valuable tool for simultaneous substrate concentration determination with optode arrays.
  • The developed method demonstrates effective spectral data reduction and accurate quantitative analysis.
  • This approach offers a robust solution for analyzing complex pharmaceutical mixtures.