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Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining
Published on: December 23, 2016
B-virus from pet macaque monkeys: an emerging threat in the United States?
S R Ostrowski1, M J Leslie, T Parrott
1Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Abstract:
Of primary concern when evaluating macaque bites are bacterial and B-virus infections. B-virus infection is highly prevalent (80% to 90%) in adult macaques and may cause a potentially fatal meningoencephalitis in humans. We examined seven nonoccupational exposure incidents involving 24 persons and eight macaques. Six macaques were tested for herpes B; four (67%) were seropositive. A common observation was that children were more than three times as likely to be bitten than adults. The virus must be assumed to be a potential health hazard in macaque bite wounds; this risk makes macaques unsuitable as pets.
Insights
Macaque bites pose serious risks due to potential B-virus infections, which can be fatal to humans. Due to the high prevalence of this virus and increased risk to children, macaques are unsuitable as pets.
Area of Science:
- Veterinary Medicine
- Infectious Diseases
- Public Health
Background:
- Macaque bites present significant health risks, primarily from bacterial and B-virus infections.
- Herpes B virus (herpes B) is endemic in 80-90% of adult macaques.
- Herpes B virus can cause fatal meningoencephalitis in humans.
Purpose of the Study:
- To evaluate the risk of herpes B virus transmission from macaque bites to humans.
- To assess the prevalence of herpes B virus in macaques involved in nonoccupational exposure incidents.
- To inform public health recommendations regarding macaque ownership.
Main Methods:
- Retrospective analysis of seven nonoccupational exposure incidents.
- Involvement of 24 individuals and 8 macaques.
- Serological testing for herpes B virus in six macaques.
Main Results:
- Four out of six (67%) tested macaques were seropositive for herpes B virus.
- Children were bitten more than three times as often as adults.
- Bacterial and herpes B virus infections are primary concerns in macaque bites.
Conclusions:
- Herpes B virus is a significant potential health hazard in macaque bite wounds.
- The high prevalence of herpes B virus in macaques and its transmission risk make them unsuitable as pets.
- Public health awareness and precautions are crucial for individuals with macaque exposure.
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