Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronic leptin infusion increases arterial pressure

E W Shek1, M W Brands, J E Hall

  • 1Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505, USA.

Hypertension (Dallas, Tex. : 1979)
|February 7, 1998
PubMed
Summary

Elevated leptin levels in obesity may cause hypertension. This study found that chronic leptin infusion in rats increased arterial pressure and heart rate, suggesting a role for leptin in obesity-related high blood pressure.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A comparison of the forces exerted during laryngoscopy using disposable and non-disposable laryngoscope blades.

Anaesthesia·2003
Same author

Mechanical closure of the vocal cords with the Airway Management Device.

British journal of anaesthesia·2003
Same author

An evaluation of the modified Airway Management Device.

Anaesthesia·2003
Same author

Evaluation of personal, environmental and biological exposure of paediatric anaesthetists to nitrous oxide and sevoflurane.

Anaesthesia·2003
Same author

The rigid nasendoscope as a tool for difficult tracheal intubation: a manikin study.

Anaesthesia·2003
Same author

Adverse airway events during brief nasal inhalations of volatile anaesthetics: the effect of humidity and repeated exposure on incidence in volunteers preselected by response to desflurane.

Anaesthesia·2003

Area of Science:

  • Endocrinology
  • Cardiovascular Physiology
  • Obesity Research

Background:

  • Plasma leptin is elevated in obese humans with hypertension.
  • The direct contribution of leptin to increased arterial pressure in obesity remains unclear.
  • Investigating leptin's role in hypertension requires understanding central nervous system (CNS) versus systemic effects.

Purpose of the Study:

  • To determine if chronic leptin elevation, mimicking obesity levels, causes sustained increases in arterial pressure.
  • To differentiate between central nervous system (CNS) and systemic mechanisms of leptin's effect on blood pressure.
  • To assess leptin's impact on heart rate, food intake, and metabolic markers.

Main Methods:

  • Rats received chronic infusions of leptin via carotid arteries (CNS) or femoral vein (systemic).

Related Experiment Videos

  • Leptin was administered at low (0.1 microg/kg/min) and high (1.0 microg/kg/min) doses over distinct periods.
  • Mean arterial pressure (MAP), heart rate, food intake, blood glucose, and insulin levels were monitored.

    • Main Results:

    • High-dose leptin infusion significantly increased plasma leptin levels in both CNS and systemic groups.
    • Mean arterial pressure (MAP) and heart rate significantly increased at the high leptin dose.
    • Food intake decreased significantly, while fasting glucose and insulin levels decreased notably at the high dose.

    Conclusions:

    • Chronic elevation of circulating leptin can induce sustained increases in arterial pressure and heart rate.
    • These findings support a potential role for leptin in the development of hypertension associated with obesity.
    • Both central and systemic administration of leptin produced similar effects on cardiovascular parameters.