[Do calcium antagonists potentiate analgesia?]

Studying the analgesic action for some of the calcium antagonists (nifedipin and verapamil) we found for the middle therapeutic doses analgesic effect of similar intensity with the middle therapeutic doses for aspirin and paracetamol. While associating these substances, we obtained an enhanced analgesic effect from 50% for the substances when taken separately to 65-88% when associating calcium antagonists with analgesic and antipyretics. This interaction on the analgesic effect could be explained by the common intervention of the two groups of substances on the physiological link between prostaglandins and calcium.