Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Precipitous exit block with epicardial steroid-eluting leads

S D Beder1, K S Kuehl, R A Hopkins

  • 1Georgetown University Medical Center, Washington, D.C., USA.

Pacing and Clinical Electrophysiology : PACE
|February 10, 1998
PubMed
Summary

Steroid-eluting ventricular pacing leads showed varying long-term performance. High early pacing thresholds predict future exit block risk, especially with the 10295A lead, necessitating vigilant monitoring.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characteristics of Anabolic-Androgenic Steroid-Free Competitive Male and Female Bodybuilders.

The Physician and sportsmedicine·2016
Same author

Aschoff bodies in an operatively excised mitral valve.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
Same author

Economic benefit of the PHLAME wellness programme on firefighter injury.

Occupational medicine (Oxford, England)·2013
Same author

Comparative study of laser damage threshold energies in the artificial retina.

Journal of biomedical optics·2012
Same author

A cluster of hypoplastic left heart malformation in Baltimore, Maryland.

Pediatric cardiology·2006
Same author

Relationship of hydraulic impedance and elasticity in the pulmonary artery of maturing newborn pigs.

The Journal of surgical research·2001

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Medical Device Technology

Background:

  • Steroid-eluting epicardial pacing leads are used for ventricular pacing.
  • Assessing long-term performance and identifying predictors of lead failure is crucial.

Purpose of the Study:

  • To evaluate the long-term outcomes of steroid-eluting ventricular epicardial pacing leads (Medtronic 10295A and 10295B/4965).
  • To identify early predictors of late pacing threshold increases and exit block.

Main Methods:

  • Retrospective analysis of 16 steroid-eluting ventricular epicardial pacing leads implanted in 12 patients.
  • Review of Medtronic clinical study database for early pacing thresholds (4 weeks post-implant).
  • Correlation of early thresholds with long-term lead performance and exit block.

Related Experiment Videos

Main Results:

  • Lead fracture occurred in 1 of 12 patients.
  • 8 of 11 patients had stable, low long-term pacing thresholds.
  • 3 patients experienced precipitous threshold increases, indicating exit block.
  • A 4-week post-implant pacing threshold ≥ 0.12 ms (5 V) predicted a 27.3% risk of exit block for the 10295A lead and 7.5% for the 4965 lead.

Conclusions:

  • The Medtronic 4965 steroid-eluting epicardial lead demonstrates better long-term stability than the 10295A lead.
  • Early identification of high pacing thresholds (≥ 0.12 ms at 4 weeks) is vital for predicting exit block.
  • Frequent threshold testing is recommended for patients with the 4965 lead and elevated early thresholds to detect late increases.