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Capillary electrophoresis in clinical and forensic analysis
1Department of Clinical Pharmacology, University of Bern, Switzerland.
Electrophoresis
|February 10, 1998
Summary
Capillary electrophoresis (CE) offers a powerful, economical method for separating diverse substances in clinical and forensic analysis. This review highlights key achievements and future trends in CE applications for these fields.
Area of Science:
- Analytical Chemistry
- Forensic Science
- Clinical Diagnostics
Background:
- Capillary electrophoresis (CE) has gained prominence over the last decade as an effective and economical separation technique.
- Commercial availability of automated CE instruments has spurred wider adoption and method development.
Purpose of the Study:
- To review the principles and key aspects of capillary electrophoresis (CE) based assays.
- To provide an overview of significant achievements of CE in clinical and forensic analysis.
Main Methods:
- Review of existing literature on CE applications in clinical and forensic settings.
- Discussion of CE principles, separation power, and detection schemes.
Main Results:
- CE is widely applicable for separating diverse substances, including serum proteins, hemoglobin variants, drugs, and nucleic acids.
- Validated CE assays demonstrate significant utility in clinical and forensic analysis.
Conclusions:
- Capillary electrophoresis is a versatile and sensitive tool for clinical and forensic analysis.
- Future trends indicate continued growth and innovation in CE-based diagnostic and forensic assays.