Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuropeptides and human sleep

A Steiger1, F Holsboer

  • 1Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany.

Sleep
|February 11, 1998
PubMed
Summary
This summary is machine-generated.

Neuropeptides like growth hormone-releasing hormone (GHRH) and corticotropin-releasing hormone (CRH) significantly influence human sleep. Imbalances in these peptides disrupt sleep patterns, particularly with aging and depression.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Non-Response to Antidepressants: Risk Factors and Therapeutic Possibilities.

Pharmacopsychiatry·2026
Same author

Development of Superconducting On-chip Fourier Transform Spectrometers.

Journal of low temperature physics·2022
Same author

Durable memories and efficient neural coding through mnemonic training using the method of loci.

Science advances·2021
Same author

The renin secretion profile under the influence of sleep deprivation and the neuropeptides CRH and GHRH.

Psychoneuroendocrinology·2020
Same author

Salivary cortisol response to psychosocial stress in the late evening depends on CRHR1 genotype.

Psychoneuroendocrinology·2020
Same author

Background corrected measurements of optical quantities in the far-infrared spectral range.

Optics express·2019

Area of Science:

  • Neuroscience
  • Sleep Medicine
  • Endocrinology

Background:

  • Neuropeptides are increasingly recognized for their role in regulating sleep.
  • Peripheral administration of peptides alters human sleep electroencephalogram (EEG) patterns.
  • Specific neuropeptides act as common regulators for both electrophysiological and neuroendocrine sleep aspects.

Purpose of the Study:

  • To review recent research on the influence of various neuropeptides on human sleep regulation.
  • To highlight the critical role of the growth hormone-releasing hormone (GHRH) and corticotropin-releasing hormone (CRH) balance in sleep.
  • To discuss the impact of aging and depression on neuropeptide-mediated sleep disturbances.

Main Methods:

  • Review of preclinical, human, and clinical studies.

Related Experiment Videos

  • Analysis of peptide administration effects on sleep EEG and neuroendocrine markers.
  • Examination of the GHRH:CRH ratio in different physiological and pathological states.

    • Main Results:

    • GHRH promotes slow-wave sleep and growth hormone secretion while inhibiting cortisol, whereas CRH has opposing effects.
    • The GHRH:CRH ratio shifts towards CRH during aging and depression, disrupting sleep endocrine activity.
    • Several neuropeptides (galanin, growth hormone-releasing peptide, neuropeptide Y) promote sleep, while others (ACTH(4-9)) disturb it. Somatostatin and vasopressin show age-dependent effects on sleep.

    Conclusions:

    • Neuropeptide balance, particularly GHRH and CRH, is crucial for normal sleep regulation.
    • Alterations in neuropeptide signaling contribute to sleep disturbances in aging and depression.
    • Further research is needed to clarify the roles of peptides like delta sleep-inducing peptide, cholecystokinin, and thyrotropin-releasing hormone in human sleep.