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Updated: Jul 23, 2026
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
An evaluation of the markers p53 and Ki-67 for their predictive value in prostate cancer
I Uzoaru1, M Rubenstein, Y Mirochnik
1Division of Cellular Biology, Hektoen Institute for Medical Research, Chicago, IL 60612, USA.
Background And Objectives:
p53 and Ki-67 are but two markers being evaluated for their predictive value in prostate cancer. The purpose of this study was to compare p53 and Ki-67 with age, stage, Gleason score, and ploidy for their prognostic abilities in prostate cancer.
Methods:
Prostate cancer specimens from 134 patients were immunohistochemically stained for p53 and Ki-67 expression and differences evaluated by SPSS analysis of variance (ANOVA) methods. The dependent variable was patient survival and the independent variables were age, stage, Gleason score, and ploidy.
Results:
In decreasing order of prediction of survival were stage (P < 0.001), Gleason score (P < 0.001), age (P = 0.1869), Ki-67 (P = 0.2284), p53 (P = 0.4282) and ploidy (P = 0.8141).
Conclusion:
It is concluded that stage and Gleason score are significant predictors of survival while p53, Ki-67, age and ploidy are not.
