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Experience with a novel vaginal progesterone preparation in a donor oocyte program
W E Gibbons1, J P Toner, P Hamacher
1Jones Institute for Women's Health, Eastern Virginia Medical School, Norfolk 23507, USA.
Fertility and Sterility
|February 11, 1998
Summary
Vaginal progesterone gel was as effective as intramuscular progesterone for achieving pregnancies in donor egg programs. This study compared pregnancy rates and outcomes between the two methods.
Area of Science:
- Reproductive Endocrinology
- Infertility Treatments
- Assisted Reproductive Technology
Background:
- Donor egg programs are crucial for patients with premature ovarian failure or diminished ovarian reserve.
- Progesterone support is essential for successful implantation and pregnancy maintenance.
Purpose of the Study:
- To compare the efficacy of vaginal progesterone versus intramuscular (IM) progesterone in a donor egg program.
- To evaluate pregnancy rates, implantation rates, and pregnancy outcomes between the two progesterone formulations.
Main Methods:
- Prospective randomized trial involving women undergoing donor egg procedures.
- Randomization into groups receiving either IM progesterone or vaginal progesterone (Crinone 8%).
- Assessment of endometrial histology, serum progesterone levels, pregnancy occurrence, implantation, and pregnancy outcomes.
Main Results:
- No statistically significant difference in ongoing pregnancy rates (31% vs. 22%) or implantation rates (23% vs. 18%) between vaginal and IM progesterone groups.
- Endometrial histology was 'in phase' for all participants in both groups.
- Mean serum progesterone levels were higher in the IM progesterone group.
Conclusions:
- Vaginal progesterone gel (Crinone 8%) is as effective as IM progesterone for achieving clinical and ongoing pregnancies in donor egg recipients.
- The study supports the use of vaginal progesterone as a viable alternative to IM progesterone in assisted reproductive technology.