Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Phenytoin kinetics in children

R G Curless, P D Walson, D E Carter

    Neurology
    |August 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Pediatric patients with seizure disorders exhibit significantly shorter phenytoin half-lives compared to adults. This necessitates individualized dosing and close blood level monitoring in children for effective seizure management.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Massive lindane overdose with toxicokinetics analysis.

    Journal of medical toxicology : official journal of the American College of Medical Toxicology·2014
    Same author

    CD4+ immune response as a potential biomarker of patient reported inflammatory bowel disease (IBD) activity.

    Clinica chimica acta; international journal of clinical chemistry·2013
    Same author

    E2 interference effects in the 12C(α,γ0)16O reaction.

    Physical review letters·2012
    Same author

    Effects of acute and chronic arsenic exposure of human-derived keratinocytes in an In Vitro human skin equivalent system: a novel model of human arsenicism.

    Toxicology in vitro : an international journal published in association with BIBRA·2010
    Same author

    VEGF and angiogenesis in acute and chronic MOG((35-55)) peptide induced EAE.

    Journal of neuroimmunology·2009
    Same author

    Toxicity and metabolism of subcytotoxic inorganic arsenic in human renal proximal tubule epithelial cells (HK-2).

    Cell biology and toxicology·2003
    Same journal

    Phenotype, Severity, and Therapy of Patients With LRP4 Antibody-Associated Myasthenia Gravis in the German Myasthenia Gravis Registry.

    Neurology·2026
    Same journal

    Association of Changes in Intrinsic Capacity With Cognitive Decline and Dementia: A Prospective Cohort Study.

    Neurology·2026
    Same journal

    Role of the Upper Motor Neuron in the Generation of Fasciculations in Early Disease Stages of Amyotrophic Lateral Sclerosis.

    Neurology·2026
    Same journal

    Factors Associated With Disability Improvement and Worsening Independent of Attacks in Patients With AQP4-IgG+ NMOSD and MOGAD: A Multicenter Cohort Study.

    Neurology·2026
    Same journal

    Cost-Effectiveness of Intracranial Aneurysm Screening: A Systematic Review.

    Neurology·2026
    Same journal

    Rare Eating Epilepsy: Co-Occurrence of Focal Cortical Dysplasia and Gray Matter Heterotopia.

    Neurology·2026
    See all related articles

    Area of Science:

    • Pharmacology
    • Pediatric Neurology
    • Clinical Pharmacy

    Background:

    • Phenytoin is a critical anticonvulsant medication for managing seizure disorders.
    • Adult pharmacokinetics of phenytoin allow for simplified dosing due to its long half-life.
    • Limited data exist on phenytoin kinetics specifically in pediatric populations.

    Purpose of the Study:

    • To investigate the pharmacokinetic profile of phenytoin in young children with seizure disorders.
    • To compare phenytoin half-lives and volumes of distribution in children versus established adult values.
    • To inform appropriate phenytoin dosing strategies for pediatric patients.

    Main Methods:

    • Pharmacokinetic analysis of phenytoin in 11 pediatric patients (6 months to 6 years).
    • Measurement of phenytoin half-lives and volumes of distribution.

    Related Experiment Videos

  • Comparison of pediatric data with historical adult pharmacokinetic data.

    • Main Results:

    • A wide variability in phenytoin half-lives and volumes of distribution was observed in children.
    • Ten out of eleven pediatric patients demonstrated very short phenytoin half-lives, ranging from 1.2 to 6.7 hours.
    • These findings contrast sharply with the longer half-life typically seen in adult patients.

    Conclusions:

    • Current phenytoin dosage recommendations for adults are not directly applicable to young children.
    • Close monitoring of phenytoin blood levels is essential in pediatric patients.
    • Individualized dosage regimens and dose intervals are crucial for optimizing phenytoin therapy in children.