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[Massive inferior vena cava thrombosis associated with protein C deficiency. Clinical case]
1Facultad de Medicina, Universidad de Valparaíso, Hospital Naval Almirante Nef, Viña del Mar.
Revista Medica De Chile
|April 1, 1997
Insights
Inferior vena cava thrombosis is rare, often linked to anticoagulant protein deficiencies. This case highlights successful treatment of a young male
Area of Science:
- Hematology
- Vascular Medicine
- Thrombosis Research
Background:
- Inferior vena cava (IVC) thrombosis is an uncommon condition.
- Approximately 30% of cases are attributed to disruptions in the natural anticoagulant protein system.
Observation:
- A case report of an 18-year-old male presenting with IVC thrombosis.
- The thrombosis was found to be associated with a deficiency in protein C, a key anticoagulant protein.
Findings:
- Successful treatment involved a multi-modal approach.
- Intravenous streptokinase infusion for 30 hours was administered.
- Followed by a 10-day course of intravenous heparin.
- The patient was subsequently transitioned to oral anticoagulation therapy.
Implications:
- This case underscores the importance of investigating underlying coagulation disorders in young patients with IVC thrombosis.
- Highlights the efficacy of thrombolytic therapy combined with anticoagulation in managing complex IVC thrombosis.
- Suggests protein C deficiency as a significant risk factor for venous thromboembolism in adolescents.
Abstract:
Inferior vena cava thrombosis is infrequent and in 30% of cases, the potential cause is an alteration of the natural anticoagulant protein system. We report a 18 years old male with an inferior vena cava thrombosis that was associated to a protein C deficiency. He was successfully treated with an infusion of intravenous streptokinase during 30 hours and intravenous heparin during 10 days, followed by oral anticoagulation therapy.