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Updated: May 5, 2026

Author Spotlight: Detection and Treatment of Helicobacter pylori Infection
Published on: July 28, 2023
One week triple therapy for Helicobacter pylori: a multicentre comparative study. Lansoprazole Helicobacter Study
J J Misiewicz1, A W Harris, K D Bardhan
1Department of Gastroenterology and Nutrition, Central Middlesex Hospital NHS Trust, Park Royal, London, UK.
Lansoprazole, amoxicillin, and clarithromycin (LAC) and lansoprazole, metronidazole, and clarithromycin (LCM) showed high Helicobacter pylori eradication rates. LAC was most effective in patients with metronidazole-resistant H. pylori.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Pharmacology
Background:
- Helicobacter pylori eradication is crucial for healing and preventing duodenal ulcers.
- It also leads to histological resolution of chronic active gastritis.
Purpose of the Study:
- To compare the efficacy of four distinct 7-day treatment regimens for H. pylori eradication.
- Regimens included proton pump inhibitors (PPIs) and two antibiotics.
Main Methods:
- A multicenter, randomized, single-blind, parallel-group study.
- Patients with H. pylori-positive duodenal ulceration or gastritis were enrolled.
- Four regimens were compared: LAC, LAM, LCM, OAM, with specific PPIs and antibiotics at defined dosages.
Main Results:
- Eradication rates were: LAC 86.0%, LAM 66.4%, LCM 87.3%, OAM 74.6%.
- LAC and LCM were significantly more effective than LAM (p < 0.001).
- Metronidazole resistance was a key factor; regimens with metronidazole were less effective in resistant cases.
Conclusions:
- All four regimens were safe and effective for H. pylori eradication.
- LAC demonstrated superior efficacy in patients with pre-treatment metronidazole-resistant H. pylori.
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