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Malignant eccrine spiradenoma with carcinomatous and sarcomatous elements

W G McCluggage1, L J Fon, D O'Rourke

  • 1Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK.

Journal of Clinical Pathology
|February 14, 1998
PubMed
Summary

This case study describes a rare malignant eccrine spiradenoma in a 60-year-old man. The aggressive tumor, a carcinosarcoma, rapidly metastasized to lymph nodes and lungs.

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Area of Science:

  • Dermatopathology
  • Surgical Oncology
  • Oncologic Imaging

Background:

  • Eccrine spiradenoma is a benign adnexal neoplasm.
  • Malignant transformation is rare, with few reported cases.
  • Perineal involvement is an unusual presentation.

Observation:

  • A 60-year-old male presented with a perineal mass.
  • Histopathological examination revealed areas of typical eccrine spiradenoma admixed with carcinomatous and sarcomatous components.
  • Immunohistochemical and ultrastructural analyses showed no epithelial differentiation in the sarcomatous areas.

Findings:

  • The tumor was classified as a carcinosarcoma arising in eccrine spiradenoma.
  • The patient experienced an aggressive clinical course.

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  • Rapid development of nodal and pulmonary metastases was observed.

    • Implications:

    • This case highlights the aggressive potential of malignant eccrine spiradenoma.
    • Accurate diagnosis through immunohistochemistry and ultrastructural analysis is crucial.
    • Understanding the behavior of carcinosarcoma arising in eccrine spiradenoma is vital for patient management.