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Updated: Aug 4, 2026

Measurement and Analysis of Extracellular Acid Production to Determine Glycolytic Rate
Published on: December 12, 2015
Log-jam in acid-base education and investigation: why make it so difficult?
J Hooper1, W J Marshall, A L Miller
1Department of Clinical Biochemistry, Royal Brompton Hospital, London, UK.
Abstract:
Medical students frequently have difficulty in interpreting acid-base data particularly when pH values are used. The difficulty persists when students qualify and has implications for the safe management of patients who require investigation of acid-base status. Simplification of tuition is required together with a change of practice in the reporting of acid-base data by the laboratories. To improve understanding, we recommend that the teaching and reporting of acid-base status should be changed to use [H+] instead of pH, and a greater emphasis placed on the logical interpretation of primary measurements--that is [H+] and PCO2--with less reliance on derived variables.
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