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The TESS database. Use in product safety assessment

T Litovitz1

  • 1American Association of Poison Control Centers, Washington, DC, USA.

Drug Safety
|February 18, 1998
PubMed
Summary
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The Toxic Exposure Surveillance System (TESS) database tracks millions of human poison exposures, aiding pharmaceutical safety monitoring and regulatory decisions. This vital resource helps identify hazards to prevent injuries and deaths.

Area of Science:

  • Public Health
  • Toxicology
  • Pharmacovigilance

Background:

  • The American Association of Poison Control Centers maintains the Toxic Exposure Surveillance System (TESS).
  • TESS collects data from 67 US poison centers, covering 87% of the US population.
  • It contains over 20.3 million human poison exposure cases.

Purpose of the Study:

  • To highlight the importance and utility of the TESS database.
  • To demonstrate TESS's role in post-marketing surveillance and hazard identification.
  • To emphasize TESS as a resource for product safety and toxicity data.

Main Methods:

  • Data compilation from US poison control centers.
  • Inclusion of case details: substances, patient demographics, outcomes, exposure reasons, and interventions.

Related Experiment Videos

  • Analysis of poisoning cases, including pharmaceuticals and specific demographics like children under 6.

    • Main Results:

    • Pharmaceuticals implicated in 42% of TESS poisoning cases.
    • Over 53% of poisonings occur in children under 6 years.
    • In 1996, 5.7% of cases were therapeutic errors and 1.5% were adverse drug reactions.

    Conclusions:

    • TESS is crucial for identifying unsuspected hazards and informing product safety actions.
    • Utilizing TESS data can minimize injuries, deaths, and product liability.
    • TESS is an essential, though under-utilized, resource for understanding product toxicity and ensuring consumer safety.