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Related Experiment Videos

Threshold tracking techniques in the study of human peripheral nerve

H Bostock1, K Cikurel, D Burke

  • 1Sobell Department of Neurophysiology, Institute of Neurology, London, United Kingdom.

Muscle & Nerve
|February 18, 1998
PubMed
Summary

Threshold tracking techniques assess nerve excitability by examining axonal membrane properties. These methods offer insights into nerve function beyond traditional tests, particularly for metabolic and toxic neuropathies.

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Area of Science:

  • Neuroscience
  • Electrophysiology
  • Neurology

Background:

  • Conventional nerve function tests primarily assess myelin sheath integrity and conduction velocity.
  • These methods offer limited insight into the axonal membrane's properties.
  • Nerve excitability depends on axonal membrane characteristics, influenced by ion channels and pumps.

Purpose of the Study:

  • To review threshold tracking techniques for in vivo human nerve studies.
  • To highlight the sensitivity of these techniques to axonal membrane properties.
  • To discuss the potential applications and limitations of threshold tracking in clinical settings.

Main Methods:

  • Description of various threshold tracking techniques.
  • Comparison of resting threshold with thresholds altered by environmental changes, preceding impulses, or subthreshold currents.

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  • Focus on in vivo human nerve studies.

    • Main Results:

    • Threshold tracking techniques are sensitive to axonal membrane potential and its modulation.
    • These methods provide information distinct from conventional electrophysiological tests.
    • Clinical studies are limited but suggest suitability for metabolic and toxic neuropathies, with insensitivity to demyelination.

    Conclusions:

    • Threshold tracking offers a valuable approach to studying nerve excitability and axonal membrane function.
    • The techniques show promise for specific neurological conditions like metabolic and toxic neuropathies.
    • Wider availability of specialized equipment is needed to fully realize the potential of these methods.