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Resveratrol, a remarkable inhibitor of ribonucleotide reductase
M Fontecave1, M Lepoivre, E Elleingand
1Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS-CEA/CNRS/Université Joseph Fourier, Grenoble, France. Fontecav@cbcrb.ceng.cea.fr
FEBS Letters
|February 19, 1998
Abstract:
Resveratrol, a natural phytoalexin found in grapes, is well known for its presumed role in the prevention of heart disease, associated with red wine consumption. We show here that it is a remarkable inhibitor of ribonucleotide reductase and DNA synthesis in mammalian cells, which might have further applications as an antiproliferative or a cancer chemopreventive agent in humans.