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Ocular hypotensive effect of pilocarpine before and after argon laser trabeculoplasty
M A Teus1, M A Castejón, M A Calvo
1Príncipe de Asturias Hospital, University of Alcalá de Henares, Madrid, Spain.
Purpose:
The purpose of this study was to compare the hypotensive response of human glaucomatous eyes to 1% pilocarpine solution before and after argon laser trabeculoplasty.
Methods:
We designed a prospective, 'repeated measures' study comparing the ocular hypotensive effect of acutely administered 1% pilocarpine solution in 30 medically uncontrolled glaucomatous eyes, before and after argon laser trabeculoplasty.
Results:
The pilocarpine-induced IOP decrease was 3.6 +/- 0.59 mmHg before argon laser trabeculoplasty, and 1.8 +/- 0.53 mmHg after laser therapy. In both instances, the pilocarpine hypotensive effect was significantly correlated with pretreatment IOP (p = 0.02, r = 0.41 before argon laser trabeculoplasty, and p = 0.003, r = 0.52 after argon laser trabeculoplasty). We built a 'repeated measurements ANCOVA' model, and found no statistically significant difference between the pilocarpine IOP lowering effect before and after argon laser trabeculoplasty (p = 0.4).
Conclusion:
Argon laser trabeculoplasty does not modify the IOP lowering effect of 1% pilocarpine solution.