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Related Experiment Videos

Bilateral primary breast cancer

H J Kesseler, W R Grier, I Seidman

    JAMA
    |July 19, 1976
    PubMed
    Summary
    This summary is machine-generated.

    This study analyzed 967 breast cancer patients, finding that physicians detected simultaneous tumors more often than patients. Early detection methods like mammography may improve survival rates for breast cancer patients.

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    Area of Science:

    • Oncology
    • Medical Research

    Background:

    • Breast cancer treatment and outcomes have evolved significantly since the study period (1962-1972).
    • Understanding the characteristics and detection of primary and secondary breast tumors is crucial for patient management.

    Purpose of the Study:

    • To analyze treatment outcomes and tumor characteristics in a cohort of primary breast carcinoma patients.
    • To investigate the incidence and detection of second primary breast tumors.
    • To identify factors influencing tumor detection and axillary lymph node involvement.

    Main Methods:

    • Retrospective analysis of 967 patients with primary breast carcinoma treated between 1962 and 1972.
    • Review of patient records for tumor detection methods, pathological findings, family history, and axillary lymph node status.

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  • Categorization of second primary tumors into simultaneous and metachronous diagnoses.

    • Main Results:

    • Thirty-five patients (3.6%) had a second primary breast tumor, with 50% diagnosed simultaneously.
    • Physicians detected tumors more frequently than patients, except in simultaneous cases.
    • Pathological examination revealed 10% of tumors were comedo, lobular carcinoma in situ, papillary, or tubular types.
    • Axillary lymph node involvement was higher in the metachronous group (50% bilateral involvement) compared to simultaneous cases.
    • A family history of cancer was noted in 26% of patients with bilateral breast cancer.

    Conclusions:

    • Mammography, biopsies of the contralateral breast, and prophylactic mastectomy for high-risk individuals are recommended to improve survival rates.
    • Timely diagnosis and appropriate management strategies are essential for improving outcomes in breast cancer patients.
    • Further research into early detection and risk stratification can enhance breast cancer patient care.